منابع مشابه
GDF11/Myostatin and aging
aging of a multicellular organism is an intricate process that results from signaling events and age-related degeneration in cells, tissues, and organ systems. Studies in model organisms have provided evidence of unanticipated connection between local and systemic aging [1]. Research in this field is defining the key tissues that govern an organism's lifespan and the signals that convey informa...
متن کاملThe Myostatin Gene
Myostatin is an important negative regulator of muscle growth. Natural mutations and knockouts in animals produce a “double-muscled” phenotype the basis of which is a dramatic increase in muscle mass. Therapeutics that target myostatin are currently in development. There are almost no documented side effects of suppression, and early research suggests that myostatin inhibition can restore funct...
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REFERENCES 1 Harari S, Caminati A. Pulmonary Langerhans’ cell histiocytosis. Eur Respir Mon 2009; 46: 155–175. 2 Weinshilboum R, Wang L. Pharmacogenomics: bench to bedside. Nat Rev Drug Discov 2004; 3: 739–748. 3 Bakker JA, Bierau J, Drent M. Therapeutic regimens in interstitial lung disease guided by genetic screening: fact or fiction?Eur Respir J 2007; 30: 821–822. 4 Coulthard S, Hogarth L. T...
متن کاملIdentification, characterization, and quantitative expression analysis of rainbow trout myostatin-1a and myostatin-1b genes.
Myostatin is a potent negative regulator of skeletal muscle growth. Although several cDNA clones have been characterized in different vertebrates, the genomic organization and bioactivity of non-mammalian homologs have not. The intron/exon organization and promoter subsequence analysis of two rainbow trout myostatin genes, rtMSTN-1a and rtMSTN-1b (formerly 1 and 2 respectively), as well as a qu...
متن کاملBlocking Versus Non-Blocking Halo Exchange
This report describes the design, implementation and analysis of a non-blocking halo exchange routine as an alternative to the blocking halo exchange routine in the lattice Boltzmann code Ludwig. The alternative non-blocking routine is implemented in such a way to allow workcommunication overlap. Detailed benchmarks in this report show that the non-blocking version is a good alternative with so...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2002
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20021203-01